/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

4 article(s) from Nagaki, Aiichiro

Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

Kyoko Mandai,
Tetsuya Yamamoto,
Hiroki Mandai and
Aiichiro Nagaki

Beilstein J. Org. Chem. 2022, 18, 660–668, doi:10.3762/bjoc.18.67

PDF

Graphical Abstract

Scheme 1: Synthesis of cyclochexene oxide via epoxidation with air in the presence of isobutyraldehyde.

Jump to Scheme 1

Figure 1: Epoxidation of cyclohexene with air bubbling in batch at various temperature.

Jump to Figure 1

Figure 2: Schematic diagram (a) and photo (b) of the flow reactor used for cyclohexene epoxidation with air. ...

Jump to Figure 2

Figure 3: Investigation of reaction temperature in flow epoxidation of cyclohexene at residence time of 0.35 ...

Jump to Figure 3

Figure 4: Investigation of residence time in flow epoxidation of cyclohexene at 100 °C.

Jump to Figure 4

Scheme 2: Plausible reaction pathway of the epoxidation of cyclohexene with air in the flow system.

Jump to Scheme 2

Figure 5: Continuous production of cyclohexene oxide.

Jump to Figure 5

Figure 6: Effect of concentration of cyclohexene and eqivalent of aldehyde.

Jump to Figure 6

Album

Supp Info

Letter

Published 13 Jun 2022

Full text

Flow microreactor synthesis in organo-fluorine chemistry

Hideki Amii,
Aiichiro Nagaki and
Jun-ichi Yoshida

Beilstein J. Org. Chem. 2013, 9, 2793–2802, doi:10.3762/bjoc.9.314

PDF

Graphical Abstract

Scheme 1: Direct fluorination using microreactor systems.

Jump to Scheme 1

Scheme 2: Use of DAST in continuous-flow reactors.

Jump to Scheme 2

Scheme 3: Flow microreactor synthesis of fluorinated epoxides.

Jump to Scheme 3

Scheme 4: Highly controlled isomerization of gem-difluoroalkenes.

Jump to Scheme 4

Scheme 5: Flow system for catalytic aromatic fluorination.

Jump to Scheme 5

Scheme 6: Continuous-flow reactor for electrophilic aromatic fluorination.

Jump to Scheme 6

Scheme 7: Examples of [¹⁸F]-radiolabeled molecular imaging probes.

Jump to Scheme 7

Scheme 8: Flow microreactor synthesis of dipeptides.

Jump to Scheme 8

Scheme 9: Flow synthesis involving S_NAr reactions.

Jump to Scheme 9

Scheme 10: Flow synthesis of fluoroquinolone antibiotics.

Jump to Scheme 10

Scheme 11: Highly controlled formation of PFPMgBr.

Jump to Scheme 11

Scheme 12: Selective flow synthesis of photochromic diarylethenes.

Jump to Scheme 12

Scheme 13: Flow microreactor system for perfluoroalkylation by generation of perfluoroalkyllithiums in the pre...

Jump to Scheme 13

Scheme 14: Integrated flow microreactor system for perfluoroalkylation by generation of perfluoroalkyllithiums...

Jump to Scheme 14

Album

Review

Published 05 Dec 2013

Full text

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl₃ promoted homocoupling

Aiichiro Nagaki,
Yuki Uesugi,
Yutaka Tomida and
Jun-ichi Yoshida

Beilstein J. Org. Chem. 2011, 7, 1064–1069, doi:10.3762/bjoc.7.122

PDF

Graphical Abstract

Scheme 1: Halogen–lithium exchange of p-bromoanisole followed by reaction with methanol.

Jump to Scheme 1

Figure 1: Flow microreactor system for halogen–lithium exchange of aryl halide followed by reaction with meth...

Jump to Figure 1

Figure 2: Effects of the temperature (T) and the residence time in R1 (t^R1) on the yield of anisole in the Br...

Jump to Figure 2

Scheme 2: Halogen-lithium exchange of p-bromoanisole followed by oxidative homocoupling with FeCl₃.

Jump to Scheme 2

Figure 3: Integrated flow microreactor system for oxidative homocoupling reaction of aryllithium with FeCl₃. ...

Jump to Figure 3

Figure 4: Effects of the temperature (T) and the residence time in R2 (t^R2) on the yield of 4,4'-dimethoxybip...

Jump to Figure 4

Album

Supp Info

Full Research Paper

Published 02 Aug 2011

Full text

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

Aiichiro Nagaki,
Naofumi Takabayashi,
Yutaka Tomida and
Jun-ichi Yoshida

Beilstein J. Org. Chem. 2009, 5, No. 16, doi:10.3762/bjoc.5.16

PDF

Graphical Abstract

Scheme 1: Sequential introduction of two electrophiles onto dibromobiaryls using Br-Li exchange reactions.

Jump to Scheme 1

Scheme 2: Br-Li exchange reaction of 2,2′-dibromobiphenyl (1) with n-BuLi using a conventional macrobatch rea...

Jump to Scheme 2

Figure 1: Microflow system for Br-Li exchange reaction of 2,2′-dibromobiphenyl (1). T-shaped micromixer: M1 (...

Jump to Figure 1

Figure 2: Effect of temperature and residence time in Br-Li exchange reaction of 2,2′-dibromobiphenyl (1) usi...

Jump to Figure 2

Figure 3: A microflow system for sequential introduction of two electrophiles. T-shaped micromixer: M1 (ø = 2...

Jump to Figure 3

Scheme 3: Br-Li exchange reaction of 4,4′-dibromobiphenyl (17) with n-BuLi using a conventional macrobatch re...

Jump to Scheme 3

Figure 4: Microflow system for Br-Li exchange reaction of 4,4′-dibromobiphenyl (17). T-shaped micromixer: M1 ...

Jump to Figure 4

Figure 5: Effect of temperature and residence time in Br-Li exchange reaction of 4,4′-dibromobiphenyl (17) us...

Jump to Figure 5

Album

Supp Info

Full Research Paper

Published 29 Apr 2009

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / Alerts / Privacy Policy / Terms & Conditions / Impressum

Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

Flow microreactor synthesis in organo-fluorine chemistry

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl₃ promoted homocoupling